Our Gene Regulation lab is located in the University of Essex in a historic town Colchester. We are interested in quantitative aspects of gene regulation in chromatin using approaches of biophysics, bioinformatics and next generation sequencing. We work on biomedical systems ranging from mouse embryonic stem cell differentiation to human cell lines to actual cancer patients (chronic lymphocytic leukemia, glioblastoma, breast cancer).
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Current lab members
Lab head, interested in chromatin and gene regulation; teaching enthusiast and open science addict.
Epigenomics enthusiast, developing cell-free DNA-based assays for liquid biopsy diagnostics
CTCF fan, working on CTCF’s role in gene expression changes in normal and cancer cells
MSD student passionate about molecular biology and genomics, working on nucleosomics of cell-free DNA in breast cancer
MSD student working on nucleosome repositioning in brain tumours. Interested in bioinformatics and sports enthusiast
Medical doctor and MSc student, working on diagnostics of lung cancer. Also interested in oral and maxillofacial cancer and athletics aficionado
MSc student working in nucleosome positioning in chronic lymphocytic leukaemia
Previous lab members
Dr Christopher Clarkson, PhD student (2017-2020). Currently in University College London
Dr Graeme Thorn, postdoctoral fellow (2017-2018). Currently in Queen Mary University of London
Dr Svetlana Gretton, postdoctoral fellow (2017). Currently in University of Suffolk
Dr Ioanna Pavlaki, postdoctoral fellow (2016). Currently in Institute of Molecular Biology, Mainz
Joshua Burton, MSc student (2016). Currently in Oslo Metropolitan University
Dr Tanvi Sharma, MSc student (2016). Currently in German Cancer Research Center, Heidelberg
Navid Shafiei, MSc student (2017). Currently teaches in William De Ferrers School, Chelmsford
Christopher Armstrong, MSc student (2018)
Ralph Samarista, Wellcome Trust Summer Student (2018). Currently in Queen’s University Belfast
Graduated from U of Essex, currently MPhil in the University of Cambridge, working on chromatin changes in chronic lymphocytic leukaemia
Enthusiastic postgraduate student, project on the computational analysis of nucleosome repositioning in breast cancer
PhD student passionate about chromatin topology and machine learning; Lacrosse player, Pint of Science co-organiser.
Genomics aficionado, working on a masters dissertation devoted to nucleosome positioning in glioblastoma
Passionate about machine learning and data science, especially applications to (epi)genomics of ageing”
– Ashkan Mohseni Hosseini
Curiosity-driven individual interested in bioinformatics, genetics and environmental science
– Emma Deeks
An aspiring stem cell researcher interested in bioinformatics and regenerative medicine. Also a music lover and film aficionado
– Ralph Samarista
Interested in cancer biology in general and nucleosome repositioning in cancer specifically.
Cancer researcher working on a masters dissertation on nucleosome positioning in chronic lymphocytic leukaemia
– Chelsea Fox
UoE graduate and visiting scientist, working on cfDNA to develop liquid-biopsy biomarkers for diagnosis.