Fragile Nucleosome
Fragile Nucleosome is an international community of scientists interested in chromatin and gene regulation. Fragile Nucleosome is active in several spaces: one is the Discord server where several hundred scientists chat informally on scientific matters. You can join the Fragile Nucleosome Discord server. Another activity of the group is the organisation of weekly virtual seminars on Zoom. Our webinars are being conducted on Wednesdays 9am Pacific time (5pm UK, 6pm Central Europe). Most previous seminars have been recorded and can be viewed at our YouTube channel. The schedule of upcoming webinars is shown below. Our third activity are weekly journal clubs detailed at a separate page (Fragile Nucleosome Journal Club). Our fourth activity which is currently in development is the mentorship program for which you can sign up at the Discord server. Please note that this web site also contains an integrated calendar with all webinars related to gene regulation (not limited to Fragile Nucleosome) at a separate page.
If you want to be reminded about upcoming events (listed below) please subscribe to the mailing list here.
Organisers:
Christine Cucinotta (Fred Hutchinson Cancer Research Center)
Hanneke Vlaming (Harvard Medical School)
Melvin Noe Gonzalez (The Francis Crick Institute)
Pravrutha Raman (Fred Hutchinson Cancer Research Center)
Ben Martin (Harvard Medical School)
Vladimir Teif (University of Essex)
Fragile Nucleosome events have been attended by >2,500 scientists from >45 countries highlighted below
Upcoming Seminars
23
September 2020
9am PST, 5pm BST,
6pm CET, 9.30pm IST
30
September 2020
9am PST, 5pm BST,
6pm CET, 9.30pm IST
7
October 2020
9am PST, 5pm BST,
6pm CET, 9.30pm IST
14
October 2020
9am PST, 5pm BST,
6pm CET, 9.30pm IST
Past seminars:
1
April 2020
Hiten Madhani: Epigenetic memory over geological timescales
9:00am (Pacific time)
UCSF, USA
8
April 2020
Toshio Tsukiyama: Regulation of Quiescence through Chromatin
9:00am (Pacific time)
Fred Hutchinson Center, USA
15
April 2020
Susan Gasser: Histone turnover in response to DNA damage: part of the checkpoint response
9:00am (Pacific time)
Friedrich Miescher Institute, Switzerland
29
April 2020
Cynthia Wolberger: Mechanisms of cross-talk between histone ubiquitination and methylation
9:00am (Pacific time)
Johns Hopkins University, USA
6
May 2020
Karolin Luger: An Epi(genetic) Battle: Nucleosomes and the Nuclear Machinery
9:00am (Pacific time)
University of Colorado Boulder, USA
13
May 2020
Tracy Johnson: A histone tale: RNA splicing and coordinated control of gene expression
9:00am (Pacific time)
UCLA, USA
20
May 2020
Sheila Teves: Transcriptional memory and dynamics in embryonic stem cells
9:00am (Pacific time)
University of British Columbia, Canada
27
May 2020
Fred van Leeuwen: Unraveling chromatin mechanisms by DNA barcoding
9:00am (Pacific time)
Netherlands Cancer Institute
3
June 2020
Alistair Boettiger: Visualizing genome folding and gene expression in development
9:00am (Pacific time)
Stanford University, USA
11
June 2020
Don and Ada Olins: Nuclear architectural plasticity and stability in a myeloid cell
9:00am (Pacific time)
University of New England, USA
17
June 2020
Rob Beagrie (Douglas Higgs group): In vivo dynamics of transcription, chromatin and genome organization during mouse erythroid differentiation
9:00am (Pacific time)
University of Oxford, UK
17
June 2020
Siyuan (Steven) Wang: Multiplexed imaging of nucleome architectures in single cells of mammalian tissue
9:30am (Pacific time)
Yale University, USA
24
June 2020
Angelika Feldmann (Rob Klose Lab): Cohesin disrupts polycomb-dependent chromosome interactions in ESCs
9:00am (Pacific time)
University of Oxford, UK
24
June 2020
Andrew Pospisilik: Epigenetics, bistability and probabilistic metabolic disease
9:30am (Pacific time)
Van Andel Institute, USA
1
July 2020
Apoorva Baluapuri (Elmar Wolf Lab): MYC Recruits SPT5 to RNA Pol II to Promote Processive and Directional Transcription Elongation
9:00am (Pacific time)
Biozentrum Würzburg, Germany
1
July 2020
Gabe Zentner: Transcription start sites earn their STRIPEs
9:30am (Pacific time)
Indiana University, USA
8
July 2020
Natalia Kochanova (Bill Earnshaw Lab): A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation
9:00am (Pacific time)
University of Edinburgh, UK
8
July 2020
Tobias Warnecke: Histones in archaea
9:30am (Pacific time)
Imperial College London, UK
15
July 2020
Aleksandra Skrajna (Robert McGinty Lab): Deciphering the nucleosome interactome
9:00am (Pacific time)
University of North Carolina, USA
15
July 2020
Emma Morrison: Nucleosome Composition Regulates the H3 Tail Conformational Ensemble and Accessibility
9:30am (Pacific time)
Medical College of Wisconsin, USA
22
July 2020
Daria Shlyueva (Kristian Helin Lab): Integrated approach to study cell cycle-dependent chromatin dynamics
9:00am (Pacific time)
MSKCC, USA
22
July 2020
Vijay Ramani: Massively multiplex single-molecule oligonucleosome profiling
9:30am (Pacific time)
UCSF, USA
29
July 2020
Lucas Farnung (Patrick Cramer Lab): Chromatin transcription: cryo-EM structures of Pol II-nucleosome and nucleosome-CHD complexes
3:00am (Pacific time)
MPI-BPC Göttingen, Germany
29
July 2020
Hitoshi Kurumizaka: Dynamic structural changes in the nucleosome during gene regulation
3:30am (Pacific time)
University of Tokyo, Japan
5
August 2020
Nathan Gamarra (Geeta Narlikar Lab): Allosteric dynamics in the nucleosome acidic patch control the chromatin remodeler SNF2h
9:00am (Pacific time)
UCSF, USA
5
August 2020
Felix Mueller-Planitz: The biogenesis and function of nucleosome arrays
9:30am (Pacific time)
TU Dresden, Germany
12
August 2020
Henry Fabian Thomas (Christa Buecker Lab): Genetic dissection of the Fgf5 enhancer cluster
9:00am (Pacific time)
MPL Vienna, Austria
12
August 2020
Srinivas Ramachandran: Cooperative binding of transcription factors is a hallmark of active enhancers
9:30am (Pacific time)
University of Colorado, USA
19
August 2020
Madeline Keenen: Static DNA compaction by the dynamic binding protein Heterochromatin Protein-1
9:00am (Pacific time)
UCSF, USA
19
August 2020
Sebastian Marquardt: Epigenetics of Genomic Punctuation
9:30am (Pacific time)
University of Copenhagen, Denmark
26
August 2020
Rodrigo Arzate: In situ dissection of domain boundaries in Drosophila
9:00am (Pacific time)
UNAM, México
26
August 2020
Yvonne Fondufe-Mittendorf: Gene expression reprogramming in response to an environmental cue
9:30am (Pacific time)
University of Kentucky, USA
2
September 2020
Kelsey Lynch: Adenovirus protein VII hijacks host chromatin factors to undermine the cell cycle
9:00am (Pacific time)
Fred Hutchinson Center, USA
2
September 2020
Siavash Kurdistani: Histones as facilitators of eukaryogenesis
9:30am (Pacific time)
UCLA, USA
9
September 2020
Giacomo Corleone: AATF-induced chromatin shifts actively sustain Multiple Myeloma progression
9:00am (Pacific time)
IRCCS National Cancer Institute, Italy
9
September 2020
Effie Kostareli: BTK signalling and enhancer landscape in Chronic Lymphocytic Leukaemia
9:30am (Pacific time)
Queen’s University Belfast, UK