Fragile Nucleosome

Fragile Nucleosome is an international community of scientists interested in chromatin and gene regulation. Fragile Nucleosome is active in several spaces: one is the Discord server where several hundred scientists chat informally on scientific matters. You can join the Fragile Nucleosome Discord server. Another activity of the group is the organisation of weekly virtual seminars on Zoom. Our webinars are being conducted on Wednesdays 9am Pacific time (5pm UK, 6pm Central Europe). Most previous seminars have been recorded and can be viewed at our YouTube channel. The schedule of upcoming webinars is shown below. Our third activity are weekly journal clubs detailed at a separate page (Fragile Nucleosome Journal Club). Our fourth activity which is currently in development is the mentorship program for which you can sign up at the Discord server. Please note that this web site also contains an integrated calendar with all webinars related to gene regulation (not limited to Fragile Nucleosome) at a separate page

If you want to be reminded about upcoming events (listed below) please subscribe to the mailing list here.

 

Organisers:

Christine Cucinotta (Fred Hutchinson Cancer Research Center)

Hanneke Vlaming (Harvard Medical School)

Melvin Noe Gonzalez  (The Francis Crick Institute)

Pravrutha Raman  (Fred Hutchinson Cancer Research Center)

Ben Martin (Harvard Medical School) 

Vladimir Teif  (University of Essex)

 

Fragile Nucleosome events have been attended by >2,500 scientists from >45 countries highlighted below

Upcoming Seminar


25

November 2020

9am PST, 5pm BST, 

6pm CET, 9.30pm IST

Joanna Achinger-Kawecka (Susan Clark lab, Garvan Institute of Medical Research, Australia)
Title TBA

Wendy Bickmore (University of Edinburgh, UK)

Moving apart for activation and clustering for repression

Past seminars:

1

April 2020

Hiten Madhani: Epigenetic memory over geological timescales

9:00am (Pacific time)

UCSF, USA

8

April 2020

Toshio Tsukiyama: Regulation of Quiescence through Chromatin


9:00am (Pacific time)

Fred Hutchinson Center, USA

15

April 2020

Susan Gasser: Histone turnover in response to DNA damage: part of the checkpoint response


9:00am (Pacific time)

Friedrich Miescher Institute, Switzerland

29

April 2020

Cynthia Wolberger: Mechanisms of cross-talk between histone ubiquitination and methylation


9:00am (Pacific time)

Johns Hopkins University, USA

6

May 2020

Karolin Luger: An Epi(genetic) Battle: Nucleosomes and the Nuclear Machinery

9:00am (Pacific time)

University of Colorado Boulder, USA

13

May 2020

Tracy Johnson: A histone tale: RNA splicing and coordinated control of gene expression


9:00am (Pacific time)

UCLA, USA

20

May 2020

Sheila Teves: Transcriptional memory and dynamics in embryonic stem cells


9:00am (Pacific time)

University of British Columbia, Canada

27

May 2020

Fred van Leeuwen: Unraveling chromatin mechanisms by DNA barcoding


9:00am (Pacific time)

Netherlands Cancer Institute

3

June 2020

Alistair Boettiger: Visualizing genome folding and gene expression in development

9:00am (Pacific time)

Stanford University, USA

11

June 2020

Don and Ada Olins: Nuclear architectural plasticity and stability in a myeloid cell


9:00am (Pacific time)

University of New England, USA

17

June 2020

Rob Beagrie (Douglas Higgs group): In vivo dynamics of transcription, chromatin and genome organization during mouse erythroid differentiation


9:00am (Pacific time)

University of Oxford, UK

17

June 2020

Siyuan (Steven) Wang: Multiplexed imaging of nucleome architectures in single cells of mammalian tissue


9:30am (Pacific time)

Yale University, USA

24

June 2020

Angelika Feldmann (Rob Klose Lab): Cohesin disrupts polycomb-dependent chromosome interactions in ESCs


9:00am (Pacific time)

University of Oxford, UK

24

June 2020

Andrew Pospisilik: Epigenetics, bistability and probabilistic metabolic disease


9:30am (Pacific time)

Van Andel Institute, USA

1

July 2020

Apoorva Baluapuri (Elmar Wolf Lab): MYC Recruits SPT5 to RNA Pol II to Promote Processive and Directional Transcription Elongation


9:00am (Pacific time)

Biozentrum Würzburg, Germany

1

July 2020

Gabe Zentner: Transcription start sites earn their STRIPEs


9:30am (Pacific time)

Indiana University, USA

8

July 2020

Natalia Kochanova (Bill Earnshaw Lab): A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation


9:00am (Pacific time)

University of Edinburgh, UK

8

July 2020

Tobias Warnecke: Histones in archaea


9:30am (Pacific time)

Imperial College London, UK

15

July 2020

Aleksandra Skrajna (Robert McGinty Lab): Deciphering the nucleosome interactome


9:00am (Pacific time)

University of North Carolina, USA

15

July 2020

Emma Morrison: Nucleosome Composition Regulates the H3 Tail Conformational Ensemble and Accessibility


9:30am (Pacific time)

Medical College of Wisconsin, USA

22

July 2020

Daria Shlyueva (Kristian Helin Lab): Integrated approach to study cell cycle-dependent chromatin dynamics


9:00am (Pacific time)

MSKCC, USA

22

July 2020

Vijay Ramani: Massively multiplex single-molecule oligonucleosome profiling


9:30am (Pacific time)

UCSF, USA

29

July 2020

Lucas Farnung  (Patrick Cramer Lab): Chromatin transcription: cryo-EM structures of Pol II-nucleosome and nucleosome-CHD complexes


3:00am (Pacific time)

MPI-BPC Göttingen, Germany

29

July 2020

Hitoshi Kurumizaka: Dynamic structural changes in the nucleosome during gene regulation


3:30am (Pacific time)

University of Tokyo, Japan

5

August 2020

Nathan Gamarra  (Geeta Narlikar Lab): Allosteric dynamics in the nucleosome acidic patch control the chromatin remodeler SNF2h


9:00am (Pacific time)

UCSF, USA

5

August 2020

Felix Mueller-Planitz: The biogenesis and function of nucleosome arrays


9:30am (Pacific time)

TU Dresden, Germany

12

August 2020

Henry Fabian Thomas  (Christa Buecker Lab): Genetic dissection of the Fgf5 enhancer cluster


9:00am (Pacific time)

MPL Vienna, Austria

12

August 2020

Srinivas Ramachandran: Cooperative binding of transcription factors is a hallmark of active enhancers


9:30am (Pacific time)

University of Colorado, USA

19

August 2020

Madeline Keenen: Static DNA compaction by the dynamic binding protein Heterochromatin Protein-1


9:00am (Pacific time)

UCSF, USA

19

August 2020

Sebastian Marquardt: Epigenetics of Genomic Punctuation


9:30am (Pacific time)

University of Copenhagen, Denmark

26

August 2020

Rodrigo Arzate: In situ dissection of domain boundaries in Drosophila


9:00am (Pacific time)

UNAM, México

26

August 2020

Yvonne Fondufe-Mittendorf: Gene expression reprogramming in response to an environmental cue


9:30am (Pacific time)

University of Kentucky, USA

2

September 2020

Kelsey Lynch: Adenovirus protein VII hijacks host chromatin factors to undermine the cell cycle


9:00am (Pacific time)

Fred Hutchinson Center, USA

2

September 2020

Siavash Kurdistani: Histones as facilitators of eukaryogenesis


9:30am (Pacific time)

UCLA, USA

9

September 2020

Giacomo Corleone: AATF-induced chromatin shifts actively sustain Multiple Myeloma progression


9:00am (Pacific time)

IRCCS National Cancer Institute, Italy

9

September 2020

Effie Kostareli: BTK signalling and enhancer landscape in Chronic Lymphocytic Leukaemia


9:30am (Pacific time)

Queen’s University Belfast, UK

23

September 2020

Danny Conrad: Sample Multiplexing in Single-Cell Epigenomic Assays


9:00am (Pacific time)

UCSF, USA

23

September 2020

Naama Barkai: Profiling nucleosome exchange using cell-intrinsic ‘timer’


9:30am (Pacific time)

Weizmann Institute, Israel

30

September 2020

Donya Shodja: Expansion of a pre-existing signaling center underlies the evolution of a morphological novelty in the Drosophila genitalia


9:00am (Pacific time)

University of Pittsburgh, USA

30

September 2020

Mary Gehring: Plant gene imprinting dynamics across multiple scales


9:30am (Pacific time)

MIT, USA

7

October 2020

Elizabeth Ing-Simmons: Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning


9:00am (Pacific time)

MPI Molecular Biomedicine, Muenster

7

October 2020

Josh Tycko: High-throughput discovery and characterization of human transcriptional effectors


9:30am (Pacific time)

Stanford, USA

14

October 2020

Maggie Chassé: Mithramycin inhibits SWI/SNF to induce promoter reprogramming and differentiation in rhabdoid tumor


9:00am (Pacific time)

Van Andel Institute, USA

14

October 2020

Sarah Hainer: Profiling of Pluripotency Factors in Single Cells and Early Embryos


9:30am (Pacific time)

University of Pitsburghs, USA

21

October 2020

Mathias Nielsen: The role of accessory proteins in epigenetic switching at a plant locus


9:00am (Pacific time)

John Innes Centre, UK

21

October 2020

Argyris Papantonis: The role of RNA polymerase II in genome reorganisation after mitosis and its link to loop extrusion


9:30am (Pacific time)

University of Göttingen, Germany

28

October 2020

Inwha Baek: Single molecule studies of RNA polymerase II transcription initiation and elongation


9:00am (Pacific time)

Harvard Medical Schoola, USA

28

October 2020

Karen Arndt: Analysis of proteins at the interface of chromatin and transcription


9:30am (Pacific time)

University of Pittsburgh, USA

4

November 2020

Yanfeng He: Elongin contributes to activator-dependent transcription


9:00am (Pacific time)

Stowers Institute, USA

4

November 2020

François Robert: Transcription and chromatin remodeler Chd1 join forces to convey FACT to genes


9:30am (Pacific time)

Montreal Clinical Research Institute

11

November 2020

Porfirio Quintero-Cadena: RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting


9:00am (Pacific time)

Caltech, USA

11

November 2020

Montserrat Anguera: Dynamic X chromosome Inactivation Maintenance in the Immune System


9:30am (Pacific time)

University of Pennsylvania, USA

18

November 2020

Ália dos Santos: DNA damage alters nuclear mechanics through chromatin reorganisation


9:00am (Pacific time)

University of Sheffield, UK

18

November 2020

Genevieve Almouzni: Histone H3 variants and their challenges,  in and out and back again


9:30am (Pacific time)

Institut Curie, France