Stable nucleosomes of the human genome

Below is the database of regions with stable nucleosome occupancy in the human genome, calculated based on MNase-seq in B-cells and cell-free DNA in patients and healthy controls. This section is part of NucPosDB, a central nucleosome positioning database.


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The stable-nucleosome regions provided below were reconstructed per-condition, based on the corresponding datasets of all mapped cfDNA fragments from Snyder et al 2016, Song et al 2017, Butler et al 2015 and Ma et al, 2017, as well as the high-resolution dataset of MNase-seq in lymphoblastoid B-cells from Gaffney et a., 2012. Per-condition datasets of stable nucleosomes are organised in these directories:

stable-nucleosome regions per-condition (hg38)

stable-nucleosome regions per-condition (hg19) 

Below we provide the histograms of fragment size distribution for conditions where at least two datasets are reported by independent laboratories or where separate per-patient datasets are available. The datasets with all mapped DNA fragments can be found in the main cfDNA repository.

cfDNA in breast cancer:

cfDNA breast cancer