Calendar of gene regulation events online
The calendar below lists webinars and meetings relevant to gene regulation. All times below are in GMT (London, UK). The link to export these events to Outlook or Google Calendar is at the bottom of this page. The calendar below includes all virtual events related to gene regulation, not limited to those organised by Fragile Nucleosome. To add your own virtual event that is not yet in our list, please email [email protected]. For a list of conferences and schools in the area of gene regulation, see the separate page “conferences, meetings and schools”. Also, have a look at complementary lists of webinars at The Node (developmental biology and related subjects), Physics of Life (biophysics) and mathseminars.org (mathematics & physics).
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Micro-C and Hi-C Webinar: Using MNase for chromatin conformation capture
September 16, 2020 @ 1:00 pm - 2:00 pm UTC+0
Free
We would like to invite you to a virtual webinar on Wed 16th September @ 14.00 UK | 15.00 CET | 16.00 EET.
This webinar will focus on Micro-C in transcriptional regulation and 3D chromatin structure as well as outline the advantages of Micro-C compared to traditional restriction-enzyme based Hi-C.
Please sign up on our Slack Channel, the Zoom link for the webinar will be posted here!
Event Slack Channel Registration: https://join.slack.com/t/dovetail-genomics-llc/shared_invite/zt-gxe842xh-RV3UYteeMc7e756FGvqojg
Micro-C: Using MNase for chromatin conformation capture at the nucleosome level
The discovery of chromatin capture methods, such as Hi-C, has enabled the study of chromatin conformation and its role in gene regulation. However widespread use of restriction enzymes for chromatin fragmentation limits assay functional resolution and ultimately the types of features that can be visualized in the contact matrix.
Use of Micrococcal nuclease (MNase) to digest chromatin in a Hi-C assay, termed Micro-C, overcomes this barrier by enriching for uniform nucleosome-sized fragments. The resulting data increases assay performance and efficiency, enabling detection of and reducing the sequencing burden required for the detection of higher resolution and existing chromatin features respectively.
In our webinar, we will discuss Micro-C’s ability to capture, Enhancer-Promoter, Promoter-Promoter, and loop extrusion features that are missed with standard Hi-C approaches. By preserving the large-scale chromatin features such as A/B compartments, TADs, and CTCF mediated loops while enabling the description of chromatin at sub-TAD scales, Micro-C provides, a new ultra-resolution view of chromatin biology emerges.