Fragile Nucleosome

Fragile Nucleosome is an international community of scientists interested in chromatin and gene regulation. Fragile Nucleosome is active in several spaces: one is the Discord server where several hundred scientists chat informally on scientific matters. You can join the Fragile Nucleosome Discord server. Another activity of the group is the organisation of weekly virtual seminars on Zoom. Our webinars are usually conducted on Wednesdays 9am Pacific time (5pm UK, 6pm Central Europe). Most previous seminars have been recorded and can be viewed at our YouTube channel. The schedule of upcoming webinars is shown below. Our third activity is the organisation of the Fragile Nucleosome Journal Club (currently on hold). Our fourth activity is the mentorship program for which you can sign up at the Discord server. If you want to be reminded about upcoming events (listed below) please subscribe to the mailing list here.

Organisers:

Christine Cucinotta (Fred Hutchinson Cancer Research Center)

Jackson Hoffman (National Institute of Environmental Health Sciences, NIH)

Ben Martin (Harvard Medical School) 

Matteo Perino (EMBL, Heidelberg)

Pravrutha Raman  (Fred Hutchinson Cancer Research Center)

Ulduz Sobhiafshar (Roslin Inhttps://twitter.com/xlw1207stitute, University of Edinburgh)

Vlad Teif  (University of Essex)

Xiaoli Sky Wu (Cold Spring Harbor Laboratory)

More details about the Fragile Nucleosome community can be found in our publication:

Cucinotta C.E., Martin B.J.E., Noé González M., Raman P., Teif V.B., Vlaming H. (2021) Strength is in engagement. EMBO Reports 22(5), e52612. | Open access article

 

Upcoming seminars


27

March 2024

Xin Gu (Mike Greenberg Lab, Harvard, USA)

Katie Galloway (MIT, USA): Transcription-induced supercoiling couples the transcription of adjacent genes


9:00am (Pacific time)

Fragile Nucleosome Seminar

24

April 2024

Kanishk Jain (Brian Strahl lab, UNC Chapel Hill, USA)

Jordan Meier (National Cancer Institute, NIH, USA)

 


9:00am (Pacific time)

Fragile Nucleosome Seminar

8

May 2024

Reuben Franklin (Sihem Cheloufi Lab, UC Riverside)

Stefan Isaac (Stirling Churchman Lab, Harvard)

Sweta Sikder (Yamini Dalal Lab, NCI)

Wayo Matsushima (Didier Trono Lab, EPFL)


9:00am (Pacific time)

Fragile Nucleosome Seminar

22

May 2024

Yatendra Kumar (Wendy Bickmore lab, University of Edinburgh, UK)

Xueqin (Sherine) Sun (Sanford Burnham Prebys, USA)

 


9:00am (Pacific time)

Fragile Nucleosome Seminar

5

June 2024

Gali Bai (Angela Brooks lab, UC Santa Cruz, USA)

Arun Kumar Ganesan (University of New Mexico, USA)

 


9:00am (Pacific time)

Fragile Nucleosome Seminar

Past seminars:

1

April 2020

Hiten Madhani: Epigenetic memory over geological timescales

9:00am (Pacific time)

UCSF, USA

8

April 2020

Toshio Tsukiyama: Regulation of Quiescence through Chromatin


9:00am (Pacific time)

Fred Hutchinson Center, USA

15

April 2020

Susan Gasser: Histone turnover in response to DNA damage: part of the checkpoint response


9:00am (Pacific time)

Friedrich Miescher Institute, Switzerland

29

April 2020

Cynthia Wolberger: Mechanisms of cross-talk between histone ubiquitination and methylation


9:00am (Pacific time)

Johns Hopkins University, USA

6

May 2020

Karolin Luger: An Epi(genetic) Battle: Nucleosomes and the Nuclear Machinery

9:00am (Pacific time)

University of Colorado Boulder, USA

13

May 2020

Tracy Johnson: A histone tale: RNA splicing and coordinated control of gene expression


9:00am (Pacific time)

UCLA, USA

20

May 2020

Sheila Teves: Transcriptional memory and dynamics in embryonic stem cells


9:00am (Pacific time)

University of British Columbia, Canada

27

May 2020

Fred van Leeuwen: Unraveling chromatin mechanisms by DNA barcoding


9:00am (Pacific time)

Netherlands Cancer Institute

3

June 2020

Alistair Boettiger: Visualizing genome folding and gene expression in development

9:00am (Pacific time)

Stanford University, USA

11

June 2020

Don and Ada Olins: Nuclear architectural plasticity and stability in a myeloid cell


9:00am (Pacific time)

University of New England, USA

17

June 2020

Rob Beagrie (Douglas Higgs group): In vivo dynamics of transcription, chromatin and genome organization during mouse erythroid differentiation


9:00am (Pacific time)

University of Oxford, UK

17

June 2020

Siyuan (Steven) Wang: Multiplexed imaging of nucleome architectures in single cells of mammalian tissue


9:30am (Pacific time)

Yale University, USA

24

June 2020

Angelika Feldmann (Rob Klose Lab): Cohesin disrupts polycomb-dependent chromosome interactions in ESCs


9:00am (Pacific time)

University of Oxford, UK

24

June 2020

Andrew Pospisilik: Epigenetics, bistability and probabilistic metabolic disease


9:30am (Pacific time)

Van Andel Institute, USA

1

July 2020

Apoorva Baluapuri (Elmar Wolf Lab): MYC Recruits SPT5 to RNA Pol II to Promote Processive and Directional Transcription Elongation


9:00am (Pacific time)

Biozentrum Würzburg, Germany

1

July 2020

Gabe Zentner: Transcription start sites earn their STRIPEs


9:30am (Pacific time)

Indiana University, USA

8

July 2020

Natalia Kochanova (Bill Earnshaw Lab): A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation


9:00am (Pacific time)

University of Edinburgh, UK

8

July 2020

Tobias Warnecke: Histones in archaea


9:30am (Pacific time)

Imperial College London, UK

15

July 2020

Aleksandra Skrajna (Robert McGinty Lab): Deciphering the nucleosome interactome


9:00am (Pacific time)

University of North Carolina, USA

15

July 2020

Emma Morrison: Nucleosome Composition Regulates the H3 Tail Conformational Ensemble and Accessibility


9:30am (Pacific time)

Medical College of Wisconsin, USA

22

July 2020

Daria Shlyueva (Kristian Helin Lab): Integrated approach to study cell cycle-dependent chromatin dynamics


9:00am (Pacific time)

MSKCC, USA

22

July 2020

Vijay Ramani: Massively multiplex single-molecule oligonucleosome profiling


9:30am (Pacific time)

UCSF, USA

29

July 2020

Lucas Farnung  (Patrick Cramer Lab): Chromatin transcription: cryo-EM structures of Pol II-nucleosome and nucleosome-CHD complexes


3:00am (Pacific time)

MPI-BPC Göttingen, Germany

29

July 2020

Hitoshi Kurumizaka: Dynamic structural changes in the nucleosome during gene regulation


3:30am (Pacific time)

University of Tokyo, Japan

5

August 2020

Nathan Gamarra  (Geeta Narlikar Lab): Allosteric dynamics in the nucleosome acidic patch control the chromatin remodeler SNF2h


9:00am (Pacific time)

UCSF, USA

5

August 2020

Felix Mueller-Planitz: The biogenesis and function of nucleosome arrays


9:30am (Pacific time)

TU Dresden, Germany

12

August 2020

Henry Fabian Thomas  (Christa Buecker Lab): Genetic dissection of the Fgf5 enhancer cluster


9:00am (Pacific time)

MPL Vienna, Austria

12

August 2020

Srinivas Ramachandran: Cooperative binding of transcription factors is a hallmark of active enhancers


9:30am (Pacific time)

University of Colorado, USA

19

August 2020

Madeline Keenen: Static DNA compaction by the dynamic binding protein Heterochromatin Protein-1


9:00am (Pacific time)

UCSF, USA

19

August 2020

Sebastian Marquardt: Epigenetics of Genomic Punctuation


9:30am (Pacific time)

University of Copenhagen, Denmark

26

August 2020

Rodrigo Arzate: In situ dissection of domain boundaries in Drosophila


9:00am (Pacific time)

UNAM, México

26

August 2020

Yvonne Fondufe-Mittendorf: Gene expression reprogramming in response to an environmental cue


9:30am (Pacific time)

University of Kentucky, USA

2

September 2020

Kelsey Lynch: Adenovirus protein VII hijacks host chromatin factors to undermine the cell cycle


9:00am (Pacific time)

Fred Hutchinson Center, USA

2

September 2020

Siavash Kurdistani: Histones as facilitators of eukaryogenesis


9:30am (Pacific time)

UCLA, USA

9

September 2020

Giacomo Corleone: AATF-induced chromatin shifts actively sustain Multiple Myeloma progression


9:00am (Pacific time)

IRCCS National Cancer Institute, Italy

9

September 2020

Effie Kostareli: BTK signalling and enhancer landscape in Chronic Lymphocytic Leukaemia


9:30am (Pacific time)

Queen’s University Belfast, UK

23

September 2020

Danny Conrad: Sample Multiplexing in Single-Cell Epigenomic Assays


9:00am (Pacific time)

UCSF, USA

23

September 2020

Naama Barkai: Profiling nucleosome exchange using cell-intrinsic ‘timer’


9:30am (Pacific time)

Weizmann Institute, Israel

30

September 2020

Donya Shodja: Expansion of a pre-existing signaling center underlies the evolution of a morphological novelty in the Drosophila genitalia


9:00am (Pacific time)

University of Pittsburgh, USA

30

September 2020

Mary Gehring: Plant gene imprinting dynamics across multiple scales


9:30am (Pacific time)

MIT, USA

7

October 2020

Elizabeth Ing-Simmons: Independence of 3D chromatin conformation and gene regulation during Drosophila dorsoventral patterning


9:00am (Pacific time)

MPI Molecular Biomedicine, Muenster

7

October 2020

Josh Tycko: High-throughput discovery and characterization of human transcriptional effectors


9:30am (Pacific time)

Stanford, USA

14

October 2020

Maggie Chassé: Mithramycin inhibits SWI/SNF to induce promoter reprogramming and differentiation in rhabdoid tumor


9:00am (Pacific time)

Van Andel Institute, USA

14

October 2020

Sarah Hainer: Profiling of Pluripotency Factors in Single Cells and Early Embryos


9:30am (Pacific time)

University of Pitsburghs, USA

21

October 2020

Mathias Nielsen: The role of accessory proteins in epigenetic switching at a plant locus


9:00am (Pacific time)

John Innes Centre, UK

21

October 2020

Argyris Papantonis: The role of RNA polymerase II in genome reorganisation after mitosis and its link to loop extrusion


9:30am (Pacific time)

University of Göttingen, Germany

28

October 2020

Inwha Baek: Single molecule studies of RNA polymerase II transcription initiation and elongation


9:00am (Pacific time)

Harvard Medical Schoola, USA

28

October 2020

Karen Arndt: Analysis of proteins at the interface of chromatin and transcription


9:30am (Pacific time)

University of Pittsburgh, USA

4

November 2020

Yanfeng He: Elongin contributes to activator-dependent transcription


9:00am (Pacific time)

Stowers Institute, USA

4

November 2020

François Robert: Transcription and chromatin remodeler Chd1 join forces to convey FACT to genes


9:30am (Pacific time)

Montreal Clinical Research Institute

11

November 2020

Porfirio Quintero-Cadena: RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting


9:00am (Pacific time)

Caltech, USA

11

November 2020

Montserrat Anguera: Dynamic X chromosome Inactivation Maintenance in the Immune System


9:30am (Pacific time)

University of Pennsylvania, USA

18

November 2020

Ália dos Santos: DNA damage alters nuclear mechanics through chromatin reorganisation


9:00am (Pacific time)

University of Sheffield, UK

18

November 2020

Genevieve Almouzni: Histone H3 variants and their challenges,  in and out and back again


9:30am (Pacific time)

Institut Curie, France

25

November 2020

Joanna Achinger-Kawecka: 3D Epigenome Remodelling in the Endocrine-Resistant Breast Cancer


9:00am (Pacific time)

Garvan Institute, Australia

25

November 2020

Wendy Bickmore: Moving apart for activation and clustering for repression


9:30am (Pacific time)

University of Edinburgh, UK

13

January 2021

Maggie Chassé: Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor


9:00am (Pacific time)

Van Andel Research Institute, USA

13

January 2021

Fred Winston: Histone chaperones collaborate to control transcription, chromatin structure, and genome stability


9:30am (Pacific time)

Harvard Medical School, USA

27

January 2021

Christine Cucinotta:  RSC primes the quiescent genome for hypertranscription during cell cycle re-entry


9:00am (Pacific time)

Fred Hutchinson Center, USA

27

January 2021

Folkert van Werven: Noncoding transcription, chromatin states and cell fate control


9:30am (Pacific time)

Francis Crick Institute, UK

10

February 2021

Manuel Rosa-Garrido: Temporal Chromatin Structural Remodeling During Heart Failure


9:00am (Pacific time)

UCLA, USA

10

Febbruary 2021

Lluis Morey: Defining the role of LSD1/CoREST in advanced breast cancer


9:30am (Pacific time)

University of Miami, USA

24

February 2021

Ariel Afek: The impact of DNA mismatches on protein–DNA interactions


9:00am (Pacific time)

Duke University, USA

24

Febbruary 2021

Pablo Navarro Gil: Should I stay or should I go, the mitotic clash


9:30am (Pacific time)

Institut Pasteur, France

10

March 2021

Madhura De: Tinkering with the linkers: a single-molecule FRET study of the linker-DNA and the linker histone on a nucleosome


9:00am (Pacific time)

DKFZ & HITS, Germany

10

March 2021

Eileen Furlong: Chromatin topology and its role in enhancer-promoter communication and embryonic development


9:30am (Pacific time)

EMBL, Germany

24

March 2021

Rafał Donczew: BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae


9:00am (Pacific time)

Fred Hutchinson Center, USA

24

March 2021

Marjorie Brand: Transcriptional Control of Cell Fate Decisions


9:30am (Pacific time)

Ottawa Hospital Research Institute

7

April 2021

Joanna Jachowicz: Xist-mediated condensates amplify SHARP localization on the X chromosome to promote chromosome-wide transcriptional silencing


9:00am (Pacific time)

Caltech, USA

7

April 2021

Jennifer Mitchell: A flexible repertoire of transcription factor binding sites and a diversity threshold determines mammalian enhancer activity


9:30am (Pacific time)

University of Toronto, Canada

21

April 2021

James Hawley: Cis-Regulatory Element Hijacking Overshadows Topological Changes in Prostate Cancer


9:00am (Pacific time)

Princess Margaret Center, Canada

21

April 2021

Marco Trizzino: Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest differentiation in ARID1B-related neurodevelopmental disorders


9:30am (Pacific time)

Thomas Jefferson University, USA

5

May 2021

Linda Forero Quintero, “Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single copy gene”


9:00am (Pacific time)

Colorado State University, USA

5

May 2021

Mounia Lagha, “Transcriptional dynamics and memory during zygotic genome activation”


9:30am (Pacific time)

Institute of Molecular Genetics, Montpellier

12

May 2021

Julie Brind’Amour, “Maternally-inherited H3K27me3 inhibits enhancer commissioning and transcription in the early embryo”


9:00am (Pacific time)

University of British Columbia

12

May 2021

Petra Hajkova, “Epigenetic reprogramming and plasticity”


9:30am (Pacific time)

Imperial College London, UK

2

June 2021

Yadira Marie Soto-Feliciano, “Mechanisms of Transcriptional Regulation by Chromatin Adaptor Proteins”


9:00am (Pacific time)

Rockefeller University, USA

2

June 2021

Song Tan, “Recognition of the nucleosome by chromatin enzymes”


9:30am (Pacific time)

Pennsilvania State University, USA

16

June 2021

Colin Hammond, “Integrating Heat Shock Molecular Chaperones into the Histone Chaperone Network”


9:00am (Pacific time)

University of Copenhagen

16

June 2021

Motoki Takaku, “Chromatin invasion by pioneer factor and chromatin remodelers”


9:30am (Pacific time)

University of North Dakota

30

June 2021

Krishnendu Guin, “Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres”


9:00am (Pacific time)

Jawaharlal Nehru Centre

30

June 2021

Antoine Molaro, “Unusual Histones Mediate Parental Conflicts in Mammals”


9:30am (Pacific time)

Genetics, Reproduction and Development Institute

14

July 2021

Myron Evans: YBX1-mediated regulation of PRC2 controls embryonic brain development


9:00am (Pacific time)

St. Jude Children’s Research Hospital

14

July 2021

Leonie Ringrose: Take, remember, give back: what do epigenetic regulatory elements do, and are they all the same?


9:30am (Pacific time)

Humboldt University

28

July 2021

Yasuhiro Arimura: Cryo-EM structures of nucleosomes from interphase and metaphase chromosomes.


9:00am (Pacific time)

Rockefeller University, USA

28

July 2021

Lori Passmore: Mechanistic insight into mRNA cleavage and polyadenylation


9:30am (Pacific time)

MRC Laboratory of Molecular Biology

11

August 2021

Vignesh Kasinath: Structural Insights into the Recruitment and Activation of Gene Silencer PRC2


9:00am (Pacific time)

University of Colorado, USA

25

August 2021

Alicia Michael: Transcription factors interface with histones to specify DNA engagement


9:00am (Pacific time)

Friedrich Miescher Institute for Biomedical Research

25

August 2021

Archana Dhasarthy: There and back again: models to study the Epithelial-Mesenchymal transition


9:30am (Pacific time)

University of North Dakota, USA

8

September 2021

Hanneke Vlaming: INSERT-seq reveals sequence determinants of RNA polymerase II elongation


9:00am (Pacific time)

Harvard Medical School

8

September 2021

Yuan He: Structural Visualization of Chromatin Regulatory Complexes using Cryo-EM


9:30am (Pacific time)

Northwestern University, USA

6

October 2021

Ashwin Narain: Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination


9:00am (Pacific time)

University of Wuerzburg, Germany

6

October 2021

Sevinc Ercan: Topoisomerases I and II promote condensin DC translocation on DNA at different scales


9:30am (Pacific time)

New York University, USA

20

October 2021

Tyler Weaver: Structural basis for APE1 processing DNA damage in the nucleosome


9:00am (Pacific time)

University of Kansas Medical Center

20

October 2021

Sylvia Erhardt: Centromeric chromatin regulation: a balancing act to maintain genome stability


9:30am (Pacific time)

Karlsruhe Institute of Technology

3

November 2021

Sandipan Brahma: Chicken & Egg of Nucleosome Dynamics: RNA Pol II modulates BAF (SWI/SNF) nucleosome remodeling


9:00am (Pacific time)

Fred Hutchinson Cancer Research Center

3

November 2021

Laura Banaszynski: Fine-tuning chromatin function with histone variant H3.3


9:30am (Pacific time)

UT Southwestern Medical Center

17

November 2021

Xiaoli S. Wu: Essential OCT11 cofactors in normal and malignant tuft cells 


9:00am (Pacific time)

Cold Spring Harbor Laboratory

17

November 2021

Nadine Vastenhouw: The spark of life. Initiating transcription in embryos


9:30am (Pacific time)

University of Lausanne

1

December 2021

Leonie Smeenk: Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia


9:00am (Pacific time)

Erasmus Medical Center

1

December 2021

Steven West: A good beginning makes a great ending


9:30am (Pacific time)

University of Exeter

12

January 2022

Samuel Corless: Locus specific protein profiling identifies novel properties of centromeres


9:00am (Pacific time)

KITP & Heidelberg University

12

January 2022

Stephen Buratowski: Visualizing transcription activation dynamics in vitro using single-molecule microscopy


9:30am (Pacific time)

Harvard Medical School

26

January 2022

Joaquina Delas: Two distinct modes of cis-regulation control cell specification in response to Shh during spinal cord development


9:00am (Pacific time)

Francis Crick Institute, UK

26

January 2022

Tatjana Sauka-Spengler: Reconstructing gene regulatory circuits in the vertebrate neural crest


9:30am (Pacific time)

Oxford University, UK

9

February 2022

Ineke Brouwer: Dynamic epistasis reveals how chromatin remodeling regulates transcriptional bursting


9:00am (Pacific time)

Netherlands Cancer Institute

9

February 2022

Geeta Narlikar: A hexasome is the preferred substrate of the INO80 chromatin remodeling machine


9:30am (Pacific time)

UCSF, USA

23

February 2022

Tim Klingberg and Agnieszka Pancholi: RNA polymerase II clusters form in line with surface condensation on regulatory chromatin


9:00am (Pacific time)

FAU; Karlsruhe Institute of Technology

 

23

February 2022

Fei (Xavier) Chen: Transcriptional regulation by Integrator-PP2A (INTAC)


9:30am (Pacific time)

Shanghai Cancer Center

9

March 2022

Waad Albawardi: Non-repetitive nucleosome arrays form disrupted and fragile chromatin fibers


9:00am (Pacific time)

University of Edinburgh

 

9

March 2022

Shabih Shakeel: Mechanistic Insights into the Fanconi Anemia DNA Repair Pathway


9:30am (Pacific time)

WEHI

23

March 2022

Jeff Hansen: A Test of the Pioneer Factor Hypothesis


9:00am (Pacific time)

Washington University in St. Louis

 

23

March 2022

Steve DeLuca: New insights into Polycomb silencing initiation revealed by an ancient alternative somatic lineage


9:30am (Pacific time)

Brandeis University

6

April 2022

Ben Weekley: The Role of Matrix Metalloproteinase 2 (MMP-2) Mediated H3NT Proteolysis in Transcriptional Regulation


9:00am (Pacific time)

University of Southern California, USA

 

6

April 2022

Hamed S. Najafabadi: Charting the landscape of in vivo methyl-cytosine recognition by transcription factors


9:30am (Pacific time)

McGill University, Canada

20

April 2022

Kanishk Jain: Acetylation-mediated histone tail accessibility governs the read-write mechanism of H3K4 methylation


9:00am (Pacific time)

UNC Chapel Hill, USA

 

20

April 2022

Emma Farley: Affinity optimizing enhancer variants disrupt development


9:30am (Pacific time)

UCSD, USA

4

May 2022

Allison Porman Swain: From chromatin to RNA and back again: Identifying unique mechanisms of regulation in Candida and lnkRNA HOTAIR


9:00am (Pacific time)

University of Colorado, USA

 

4

May 2022

Alan Underhill: Testing the limits of heterochromatin protein dynamics


9:30am (Pacific time)

University of Alberta, Canada

18

May 2022

Nezha Benabdallah: The Central Role of H2A Ubiquitination in Synovial Sarcoma


9:00am (Pacific time)

DKFZ Heidelberg, Germany

 

18

May 2022

Karmella Haynes: Rational Design of Reader-Effectors: Synthetic Biology Meets Chromatin Epigenetics


9:30am (Pacific time)

Georgia Tech and Emory University

15

June 2022

Ivan Corbeski: Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF


9:00am (Pacific time)

University of Zurich, Germany

 

15

June 2022

Maria Cristina Gambetta: Molecular basis of gene insulation


9:30am (Pacific time)

University of Lausanne, Switzerland

29

June 2022

Petra Vizjak: Nucleosome sliding in a condensed chromatin


9:00am (Pacific time)

University of Munich, Germany

 

29

June 2022

Benjamin Garcia: Quantitative proteomics for understanding epigenetic cancer mechanisms


9:30am (Pacific time)

 Washington University, USA

13

July 2022

Alonso Pardal: Nuclear transport, chaperoning and folding of histones H3 and H4


9:00am (Pacific time)

University of Warwick, UK

27

July 2022

Emily Wheeler: Splicing modulators impair DNA damage response and induce killing of Cohesin-mutant MDS/AML


9:00am (Pacific time)

 Dana Farber Cancer Center, USA

27

July 2022

Mark Dawson: Targeting the epigenome in cancer


9:30am (Pacific time)

Peter MacCallum Cancer Center, USA

10

August 2022

Heta Patel: DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genes


9:00am (Pacific time)

  Netherlands Cancer Institute

10

August 2022

Jordan Rowley: Zooming-in to uncover precise 3D genome folding


9:30am (Pacific time)

University of Nebraska Medical Center

7

September 2022

Bruno Gegenhuber: Epigenomic programming of brain sex differences


9:00am (Pacific time)

  Harvard University, USA

7

September 2022

Eda Yildirim: Balancing X-chromosome dosage in hematopoietic cells: mechanistic insights and impact on cancer


9:30am (Pacific time)

Duke University, USA

21

September 2022

Elias Friman: Ultra-long-range interactions between active regulatory elements


9:00am (Pacific time)

  Edinburgh University, UK

21

September 2022

Charles Danko: RNA polymerase II and PARP1 shape enhancer-promoter contacts


9:30am (Pacific time)

Cornell University, USA

12

October 2022

Ben Vincent: Evo-devo in the Matrix


9:00am (Pacific time)

University of Pittsburgh, USA

12

October 2022

Yael David: Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools


9:30am (Pacific time)

Memorial Sloan Kettering Cancer Center, USA

26

October 2022

Alex Francette: The Long and Short of It: Direct and Indirect Functions of the Paf1 Complex


9:00am (Pacific time)

University of Pittsburgh, USA

26

October 2022

Seychelle Vos: Defining how sequence and local chromatin context regulate gene expression


9:30am (Pacific time)

MIT, USA

9

November 2022

Tyler Gibson: Defining properties regulating pioneer-factor binding and function


9:00am (Pacific time)

University of Wisconsin-Madison, USA

9

Novembr 2022

Ilaria Panzeri: Developmental plasticity as a predisposing factor for tumorigenesis


9:15am (Pacific time)

Van Andel Institute, USA

9

November 2022

Valentin Flury: Recycling of modified H2A-H2B provides short term memory of chromatin states


9:30am (Pacific time)

University of Copenhagen, Denmark

9

Novembr 2022

Jackson Hoffman: Chromatin accessibility and neural specification from hESC


9:15am (Pacific time)

NIEHS, USA

7

December 2022

Nitin Shirole: Role of HIF-alpha transcription factors in clear cell renal cell carcinoma


9:30am (Pacific time)

Dana Farber Cancer Institute, USA

7

December 2022

Tuğba Bağcı Önder: Epigenetic regulation of therapy response in cancers


9:15am (Pacific time)

Koç University, Turkey

21

December 2022

Zlata Gvozdenov: Distinguishing Biological Function from Biological Noise


9:00am (Pacific time)

Harvard Medical School, USA

21

December 2022

Mike Guertin: Kinetic networks of differentiation cascades identify key regulatory nodes and transcription factor functions


9:15am (Pacific time)

University of Connecticut Health, USA

18

January 2023

Ulduz Sobhiafshar: IRF4 is a critical modulator of repressive epigenetic marks and their downstream targets in melanoma cells


9:00am (Pacific time)

Boğaziçi University, Turkey

18

January 2023

Jacques Côté: Reading and writing histone marks by MYST-family acetyltransferase complexes in gene expression and oncogenesis


9:30am (Pacific time)

Laval University, Canada

1

February 2023

Dheva Setiaputra: Charting the 53BP1-RIF1-shieldin pathway and its role in DNA double-strand break repair


9:00am (Pacific time)

Lunenfeld-Tanenbaum Research Institute, Canada

1

February 2023

Felix Jonas: The molecular grammar of disordered regions guiding transcription factor genome-binding specificity


9:30am (Pacific time)

Jacobs University, Germany

15

February 2023

Nikhil Hajirnis: Re-engineering the Hox locus in Drosophila: A CRISPR/Flp based approach for understanding non-coding collinearity


9:00am (Pacific time)

University of Maryland School of Medicine, USA

15

February 2023

Brian Hendrich: Enhancer resetting: how chromatin translates signals into transcription


9:30am (Pacific time)

University of Cambridge, UK

1

March 2023

Adi Mukund: Differential Histone-DNA Interactions Dictate Nucleosome Recognition of Pioneer Transcription Factor Sox


9:00am (Pacific time)

Stanford University, USA

1

March 2023

Ezgi Karaca: Differential histone-DNA interactions dictate nucleosome recognition of pioneer transcription factor SOX


9:30am (Pacific time)

Izmir Biomedicine and Genome Center, Turkey

15

March 2023

Daniel Michelson: Gene regulation in thymic epithelial cells


9:00am (Pacific time)

Harvard Medical School, USA

15

March 2023

Mikhail Spivakov: Probing the relationship between enhancer activity, connectivity and gene expression


9:30am (Pacific time)

Imperial College London, UK

29

March 2023

Rafia Akhlaq: Epigenetic Regulation of Microglial Immune Memory


9:00am (Pacific time)

University of Karachi, Pakistan

29

March 2023

Annie Ciernia: Histone deacetylase and thioredoxin inhibitors regulating histone acetylation and methylation levels under hypoxia in oral squamous cell carcinoma in vitro


9:30am (Pacific time)

University of British Columbia, Canada

12

April 2023

Stephen Abini-Agbomson: Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1


9:00am (Pacific time)

New York University, USA

12

April 2023

Carol Chen: Germline histone H3.3 mutations in neurodegenerative disorders


9:30am (Pacific time)

University of British Columbia, Canada

26

April 2023

Komal Yasmin: Why did nature choose Dnmt3b? Investigating mechanisms governing Dnmt3b specificity for CpG Island methylation during X inactivation


9:00am (Pacific time)

University of Oxford, UK

26

April 2023

Wei Xie: Decoding the transcription circuitry in early mammalian development


9:30am (Pacific time)

Tsinghua University, China

10

May 2023

Megan Rowland: Investigating the Role of Baf53b in Neuron Development and Autism Spectrum Disorder


9:00am (Pacific time)

University of British Columbia, Canada

10

May 2023

Elizabeth Pollina: Activity-Dependent DNA Repair in Neuronal Plasticity


9:30am (Pacific time)

Washington University, USA

24

May 2023

Pia Mach: Cohesin and CTCF control the dynamics of chromosome folding


9:00am (Pacific time)

FMI, Switzerland

24

May 2023

Mia Levine: Intra-genomic conflict shapes the evolution of genome integrity


9:30am (Pacific time)

University of Pennsylvania, USA

7

June 2023

Ishtiaque Hossain: ZIC2/3 maintain bivalency and shape acquisition of essential lineage-specific cistrome during progression towards primed pluripotency


9:00am (Pacific time)

McGill University, Canada

7

June 2023

Mariam Okhovat: Unfolding the genome: a comparative investigation of mammalian TAD boundary properties and function


9am (Pacific time)

Oregon Health & Science University

7

June 2023

Khoa Tran: Spatial Regulation of Chromatin Associated Proteins During Cellular Senescence


9:00am (Pacific time)

University of Pennsylvania, USA

7

June 2023

Claudia Mimoso: U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes


9am (Pacific time)

Harvard Medical School, USA

7

June 2023

Vikram Paralkar: Cell-type-specific regulation of ribosomal RNA transcription


9:00am (Pacific time)

University of Pennsylvania, USA

21

June 2023

Alexis Stutzman: Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms


9am (Pacific time)

UNC at Chapel Hill, USA

21

June 2023

Richard Adeyemi: RAD51 regulation during the Replication Stress Response


9:00am (Pacific time)

Fred Hutchinson Cancer Center, USA

19

July 2023

Roberta Dollinger: The role of the Spt5 NGN domain in promoter proximal pausing of RNA polymerase II


9am (Pacific time)

Penn State University, USA

19

July 2023

Pradeepa Madapura: H4K16ac activates transcription of transposable elements (TEs) and contributes to their enhancer activity


9:00am (Pacific time)

Queen Mary University of London, UK

16

August 2023

Benjamin Patty: A network of nucleosome remodelers regulates non-coding RNA expression at cis-regulatory elements in embryonic stem cells


9am (Pacific time)

University of Pittsburg, USA

16

August 2023

Ralph Grand: Genome access is transcription factor specific and defined by nucleosome position


9:00am (Pacific time)

Heidelberg University, Germany

13

September 2023

Sahin Naqvi: Tuning transcription factor level to understand dosage sensitivity in development


9am (Pacific time)

Stanford University, USA

13

September 2023

Melissa Harrison: Pioneering the development frontier


9:00am (Pacific time)

University of Wisconsin – Madison, USA

27

September 2023

Lakshmi Mahendrawada: Surprising connections between DNA binding and functions of Yeast transcription factors


9am (Pacific time)

Fred Hatch Cancer Center, USA

27

September 2023

Siqi Liu: Injury repair: a host response to homeostatic disruption


9:00am (Pacific time)

UT Southwestern, USA

11

October 2023

Coral Zhou: Mechanisms of genome size control during embryogenesis and evolution


9am (Pacific time)

Fred Hatch Cancer Center, USA

11

October 2023

Irene Kaplow:  Relating enhancer genetic variation across mammals to complex phenotypes using machine learning


9:00am (Pacific time)

Duke University, USA

11

October 2023

Max Haase: Walk on the wild side: insights into histone and point centromere evolution from the bipolar budding yeasts Hanseniaspora


9am (Pacific time)

NYU, USA

11

October 2023

Shubham Tripathi: Mechanical control of transcription by DNA supercoiling


9:00am (Pacific time)

Yale University, USA

25

October 2023

Matteo Trovato: Histone H3.3 lysine 9 controls development and immune response associated sic-regulatory elements in mouse embryonic stem cells


9am (Pacific time)

EMBL, Germany

25

October 2023

Maria-Elena Torres-Padilla: Epigenetic mechanisms of cellular plasticity


9:00am (Pacific time)

Helmholtz Zentrum München, Germany

22

November 2023

Julien Richard Albert: Multiple gene regulatory mechanisms converge at the Zdbf2 locus


9am (Pacific time)

Institut Jacques Monod, CNRS, Paris

22

November 2023

Robert Scott Illingworth: Shaping the H2AK119ub landscape – The Goldilocks Principle in Neurodevelopmental Gene Regulation


9:00am (Pacific time)

University of Edinburgh, UK

6

December 2023

John Pulice: Dosage amplification dictates oncogenic regulation by the NKX2-1 lineage factor in lung adenocarcinoma


9am (Pacific time)

Harvard University, USA

6

December 2023

Benjamin Roche: Keeping it quiet: ERH is an essential repressor maintaining cellular quiescence


9:00am (Pacific time)

University of North Dakota, USA

31

January 2024

Katerina Cermakova: Dynamics of cancer addiction to SWI/SNF


9am (Pacific time)

Baylor College of Medicine, USA

31

January 2024

Richoo Davis: Prion-like low-complexity domains drive selective co-condensation of FET oncofusion proteins and mammalian SWI/SNF complex


9:00am (Pacific time)

University at Buffalo, USA