This web site is run by Vlad Teif lab . We are interested in deciphering mechanisms of gene regulation in chromatin using approaches of biophysics, bioinformatics and next generation sequencing. We work on biomedical systems ranging from stem cell differentiation to cancer (see publications). We also maintain the NucPosDB database and several community resources explained below. Feel free to contact us with suggestions of your resources and events to be included in the databases.
Our favorite games are centered around nucleosomes. We are investigating how nucleosomes interact with transcription factors and other chromatin players to fine tune gene regulation in cell differentiation and cancer transitions, and how this fundamental information can be translated in to the clinic to aid patient diagnostics, stratification and monitoring for personalised medicine.
This web site contains resources relevant to gene regulation, including nucleosome positioning (NucPosDB is a centralised database of experimental nucleosome maps in vivo, cell-free DNA (cfDNA), algorithms to predict nucleosome positioning and computational tools to analyse nucleosome positioning experiments) and protein-DNA binding (e.g. the section TF binding contains information about databases of transcription factors weight matrices, experimental binding datasets and computational tools). A frequently updated section is devoted to upcoming conferences and schools relevant to quantitative gene regulation. Recently we started maintaining the real-time calendar of online events such as webinars. In addition, we maintain a list of undergraduate research opportunities , postdoctoral and PhD fellowships, as well as travel grants. Finally, the Open Science sections contain information about the present and future of science online including the Scientific Twitter and the rapidly growing Fragile Nucleosome online discussion community.